Ekibimiz

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Prof.Dr. Devrim Gözüaçık

Koç University

Work Experience

2018-present: Part-time Senior Researcher, SUNUM Nanotechnology Research and Application Center.

 

2020-present: Research Team Leader, KUTTAM Research Center for Translational Medicine, Koç University Hospital.

 

2020-present: Tenured Professor and Research Team Leader, Koç University School of Medicine.

 

2018-present: International Council Member and Affiliate Member, Autophagy, Inflammation: and Metabolism (AIM) Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, USA.

 

2006-2020: Professor, Sabanci University, Istanbul.

 

2017-2019: Advisory Board Member, TÜSEB (Turkish NIH) Biotechnology Institute

 

2016-2020: Founding Board Member, EFSUN Center of Excellence for Nano Diagnostics.

 

2001-2006: Postdoctoral Fellow, Weizmann Institute of Science, Rehovot (Adi Kimchi Lab).

 

1997-2001: PhD Student Researcher, Pasteur Institute and Necker Children’s Hospital IRNEM, Paris (Christian Brechot Lab).

 

1996-1997: MSc Student Researcher, Ecole Polytechnique, Paris (Andrea Parmeggiani Lab).

Research Interests

Autophagy
Cancer,
Neurodegenerative diseases,
Rare diseases,
Disease markers and drug target discovery,
Nano drugs,
Targeted drug delivery,
Nanotechnology for disease diagnosis and follow-up,
Theranostics

Last 5 Publications

Unal O, Akkoc Y, Kocak M, Nalbat E, Dogan-Ekici AI, Yagci Acar H, Gozuacik Dx. Treatment of breast cancer with autophagy inhibitory microRNAs carried by AGO2-conjugated nanoparticles. J Nanobiotechnology. 2020 Apr 28;18(1):65. doi: 10.1186/s12951-020-00615-4 https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-020-00615-4

Demir-Duman F, Akkoc Y, Demirci G, Bavili N, Kiraz,A, Gozuacik Dx, Yagci Acar Hx. Bypassing pro-survival and resistance mechanisms of autophagy in EGFR-positive lung cancer cells by targeted delivery of 5FU using theranostic Ag2S quantum dots. Journal of Materials Chemistry B, 2019 Dec 14;7(46):7363-7376 https://pubs.rsc.org/en/content/articlelanding/2019/tb/c9tb01602c#!divAbstract

Yar Y, Khodadust R, Akkoc Y, Utkur M, Saritas EU, Gozuacik D, Yagci Acar Hx. Development of Tailored SPION-PNIPAM Nanoparticles by ATRP for Dually Responsive Doxorubicin Delivery and MR Imaging. Journal of Materials Chemistry B, 2018, 6, 289 – 300. (Impact factor: 4.54. Times cited: 2) https://pubs.rsc.org/en/content/articlelanding/2017/tb/c7tb00646b#!divAbstract

Demir F, Hocaoglu I,Ozturk DG, Gozuacik D, Kiraz A, Yagci Acar Hx. Highly Luminescent and Cytocompatible Cationic Ag2S NIR-emitting Quantum Dots for Optical Imaging and Gene Transfection. Nanoscale, 2015, DOI: 10.1039/C5NR00189G. (Impact factor: 7.36. Times cited: 26) https://pubs.rsc.org/en/content/articlelanding/2014/nr/c5nr00189g#!divAbstract

Gozuacik Dx, Yagci-Acar HF, Akkoc Y, Kosar A, Dogan-Ekici AI, Ekici S. Anticancer use of nanoparticles as nucleic acid carriers. Journal of Biomedical Nanotechnology, 2014, September; 10(9): 1751-1783. (Impact factor: 5. Times cited: 18) https://www.ingentaconnect.com/content/asp/jbn/2014/00000010/00000009/art00006

Patents

Gozuacik D, Kutlu O, Akkoc Y, Akkiz H. IL as a novel biomarker and drug target in fatal liver cancer. WIPO-Patent Cooperation Treaty. Application Number: PCT/TR2019/051107. December 18, 2019. Pending.

Gozuacik D, Kutlu O, Kocaturk NM, Kilislioglu A, Karakus S, Kutlu M, Ilgar M, Ben Taleb AM, Tan E. Nano formulations comprizing Ceranib-2. WIPO-Patent Cooperation Treaty. Application Number: PCT/TR2019/050247. April 16, 2019. Pending.

Akgonul S, Zuvin M, Sevgen MI, Kosar A, Gozuacik D; Kutlu O, Yagci-Acar H. Rotary Magnetic Actuation System. WIPO-Patent Cooperation Treaty. Application Number: PCT/TR2019/050115. February 20, 2019. Pending.

Gozuacik D, Ozturk DG, Kocak M. Stress-Regulated MiRNAs As Novel Cancer Biomarkers. WIPO-Patent Cooperation Treaty. Application Number: PCT/TR2019/050004. January 2, 2018. Pending.

Yagci-Acar H, Gozuacik D, Kosar A, Unal O, Kocak M, Akkoc Y, Zuvin M. Therapeutic nanoparticles containing a protein for microRNA delivery and compositions and methods using same. WIPO-Patent Cooperation Treaty. Application Number: PCT/TR2018/050094. March 10, 2018. Pending.

Kosar A, Gozuacik D, Sadaghiani AH, Motazakker A, Akkoc Y. Heat exchanger with enhanced heat transfer surfaces. Turkish Patent Institute. Application Number: 17T-10468. April 14, 2017. Pending.

Gozuacik D. Usage of FC for cancer diagnosis and treatment. European Patent Office Patent Application Number: EP3067422. March 13, 2013. Pending.
Cho YK, Bathany C, Kim JY, Gozuacik D. Device and method for single cell screening-based on inter-cellular communication. WIPO-Patent Cooperation Treaty. Patent Application Number: WO2016099207. June 23, 2016. Pending. USA Patent Office. Patent Number: 10385306. August 20, 2019. Approved.

Gozuacik D and Korkmaz G (PhD Student). Use of miRNAs for the diagnosis, propylaxis, treatment and follow-up of diseases involving macroautophagy abnormalities. European Patent Office Patent Number: EP10777121.4. April 05, 2012-2015. Approved.

Memberships

2010-today, Board of Directors Member, International Cell Death Society
(ICDS) (Based in New York) (www.celldeath-apoptosis.org)

2016-today, Founding Member, Turkish Cell Death Research Society (HOAD).

2011-today, Founding Member, Turkish Molecular Biology Society (MBD).

2016-2017, Board Member, Turkish Cell Death Research Society (HOAD).

2011-2013, Board Member, Turkish Molecular Biology Society (MBD).

Awards

2015: Elginkan Foundation Technology Award (together with the SUTAB medical device team)

2014: TGC Sedat Simavi Health Sciences Award

2014: IKU Prof. Onder Oztunali Science Award

2008: Turkish Academy of Sciences, Successful Young Scientist Award (TÜBA-GEBİP).

2006: European Molecular Biology Organization, Strategical Development and Installation Award (EMBO-SDIG).

2006: Selected by Roche Pharmaceuticals among the “Bioscience Leaders of the Next Decade”.