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ismet.gurhan@sabanciuniv.edu

Prof. Dr. S. İsmet Deliloğlu Gürhan

PhD: Virology, Selcuk University, Institute of Health Sciences, 1993

Work Experience

2022-

Consultant, MNA Laboratories Ind. Trade. Co. Ltd. Istanbul

2021-

Consultant, SIA Analysis Laboratories, Izmir.

2019-

Consultant & Part Time Researcher, Sabanci University, Nanotechnology Research and Application Centre (SUNUM).

2016 - 2022

Consultant and Visiting Researcher, Ege University, Drug Development and Pharmacokinetic Research-Application Centre (ARGEFAR), Preclinical Researches Unit

2014 - 2020

Emeritus Professor, Ege University Bioengineering Dept.

2015 - 2018

Consultant, Florabio Inc., Izmir Institute of Technology, İzmir.

2015 - 2016

Lecturer, E.U. Bioengineering Dept., Turkey and Near East University Biomedical Eng. Dept., North Cyprus

2012 - 2014

Ege University, Inst. of Science, Head of the Department of Biomedical Technology, (Deputy Head of Department ), Izmir, Turkey,

2011 - 2014

Ege University, Ethical Committee of Scientific Researches & Publications (BAYEK)

2011 - 2014

Member of Ege University, Inst. of Health Sciences, Stem Cell Department Academic Board

2010 - 2022

Technical expert, TR Ministry of Foreingn Affairs, Turkish Accreditation Agency (TURKAK), Virology and Biological Products.

2010-2014

Member of Ege University, Animal Experiments  Ethics Committee (EUHADYEK)

2005 - 2014

Ege University, Fac. Engineering, Academic Board Member

2004 - 2005

Consultant, ATA-FEN Inc., Manufacturer of Veterinary Vaccines 

2002 - 2005

Ege University, Fac. Engineering, Executive Board Member

2002 - 2004

Consultant, VETAL Serum and Biological Products Industry and Trade Inc.

2001 – 2014

Ege University, Fac. Engineering, Bioengineering Dep., Izmir, Turkey.

1994 -  2000

EU FAO/FMD, Member of FMD Research Group

1993 -  2000

TR Ministry of Agriculture, Foot & Mouth Disease Institute, Founder and Head of Animal Cell Culture Collection (HUKUK WDCM756), Ankara, Turkey.

1980 – 2001

TR Ministry of Agriculture, Foot & Mouth Disease Institute, Upstream Processing Lab. Supervisor, Ankara, Turkey.

1974 - 1976

TR Ministry of Agriculture, Foot & Mouth Disease Institute, Research Assistant, Ankara, Turkey.

1976 - 1980

TR Ministry of Agriculture, Foot & Mouth Disease Institute, Specialist Research Assistant, Ankara, Turkey.

1973 - 1974

TR Ministry of Agriculture, Çankaya District State Veterinarian, Ankara, Turkey.

1971 - 1973

TR Ministry of Agriculture, Batman District State Veterinarian, Siirt, Turkey.

1969 - 1971

TR Ministry of Agriculture, Çankaya District State Veterinarian, Ankara, Turkey.

Research Interests

  1. In vitro monoclonal antibody production in laboratory and pilot scale (hybridoma technology).
  2. Development of the cell culture systems alternative to the animal models for the toxicity testing of biological products (biocompatibility tests).
  3. Viral vaccine production and control.
  4. The effect of anticancer drugs on several tumour cell lines.
  5. Mesenchymal stem cells.
  6. Cell banks and culture collection.
  7. Virus susceptibility of the newly developed cell line sysytems.

Organizations

  1. Cell Death Research Society (HOAD) (honorary board member)
  2. Biomaterials and Tissue Engineering Society (BTES), Turkey, (board member)
  3. Turkish Biotechnology Association
  4. Veterinary Microbiology Association
  5. European Society for Animal Cell Culture (ESACT)
  6. European Society for Veterinary Virology (ESVV)
  7. European Culture Collection Organization (ECCO)
  8. Vaccine Science Society (founding member)
  9. The Chamber of Izmir Veterinary Surgeons (IVHO)

Last 5 Publications

  1. Erden Tayhan, S, Şendemir, A, Mir, E, Deliloğlu Gürhan, S.İ. A Preliminary Study for Construction of Mesenchymal Stem Cell Derived Artificial Human Urinary Bladder. (submitted).
  2. Deliloğlu-Gürhan S.I. (2022) Past and Present of the Vaccine Production in Türkiye (Türkiye’de Aşı Çalışmalarının Dünü Bugünü), (Koçdor H, Pabuççuoğlu A, Zihnioğlu F, Sağın F, eds.) Sağlık Biyoteknolojisi, 1. Baskı (1st ed.), ISBN: 978-625-401-790-2, Ankara: Türkiye Klinikleri; 31-6.
  3. Pekmez, K., Kalaycı G., Gürhan SI., Hames EE. (2020) Preparation and optimization of rapid and sensitive coagglutination test for detection of infectious pancreatic necrosis virus (IPNV) Turk J Vet Anim Sci 44, (2020), 1003-1009. doi:10.3906/vet-2002-61
  4. Kimiz-Gebologlu I, Saglam-Metiner P, Ozaslan O, Ayyildiz-Tamis D, Deliloglu-Gurhan SI, Gulce-Iz S. (2020). Development of a serum free media for HUMIRA® (Adalimumab) biosimilar as a model by design of experiment approaches, Turkish Journal of Biochemistry,1-11. https://doi.org/10.1515/tjb-2019-0268
  5. Saglam-Metiner P, Can H, Ayyildiz-Tamis D, Karakavuk M, Kimiz I, Gülce-Iz S, Atalay-Sahar E, Degirmenci-Döskaya A, Gürüz Y, Deliloglu-Gürhan SI and, Döskaya M. (2019) The use of Toxoplasma gondii tachyzoites produced in HeLa cells adhered to Cytodex 1 microcarriers as antigen in serological assays: an application of microcarrier technology. Cytotechnology, 71(1): 91-105.

Patents

  1. Monoclonal antibodies developed against h-FABP and the use thereof (H-fabp’e karşı geliştirilen monoklonal antikorlar): MÖ Özen, SI Gürhan ; TR Patent WO 2015142305 A1; Patent Sicil No: 2014/03258,; Patent Tarihi: 20/03/2014-14.32:44. Mehmet Özgün Özen, Ismet Deliloğlu Gürhan, S.K.; Teknoloji Araştırma Geliştirme San. ve Tic. Ltd. Şti. (S.K. Technology R&D Ind. and Trade Limited Comp.).
  1. Bir Bovine Papillomavirus (BPV) İnaktif Aşı Üretim Yöntemi (A bovine papillomavirus, BPV, Inactivated Vaccine Manufacturing Method); Başvuru Numarası (Submission No.): 2023/005818; Evrak Tarihi (File Date): 23.05.2023 12:12:53. Başvuru Sahipleri:  Burdur Mehmet Akif Ersoy Üniversitesi; Buluş Sahipleri:  Saime İsmet Gürhan, Yakup Sinan Orta,  Yakup Yıldırım, Mehmet Kale, Sevinç Kant

Memberships

  1. Cell Death Research Society (HOAD) (founder member)
  2. Biomaterials and Tissue Engineering Society (Turkey) (BTES), board member
  3. Turkish Biotechnology Association
  4. Veterinary Microbiology Association
  5. European Society for Animal Cell Culture (ESACT)
  6. European Society for Veterinary Virology (ESVV)
  7. European Culture Collection Organization (ECCO)
  8. Vaccine Science Society (founder member)
  9. Turkish Society of Microbiology (TMC)

Awards

  1. Anil, M., Şendemir-Ürkmez, A, Oktem, G., Deliloglu-Gürhan SI, (2013): Developing a 3D cancer tissue model with tissue engineering approach. 14th International BIOMED Symposium, 12-15 Nov. 2013, Kusadasi, Turkey. Poster. Best poster award.
  2. Anil, M., Şendemir-Ürkmez, A, Oktem, G., Deliloglu-Gürhan SI, (2013): In vitro breast cancer stem cell culture on different surface  materials, The International Symposium on Cancer Nano medicine, 07-09 Nov. 2013, Izmir, Turkey. Best poster award.
  1. Deliloglu-Gürhan SI, Şendemir-Ürkmez, A., Gorgun, C. Investigation of hypoxia on the cancer stem cells, September, 2013. Aliye Ustel Foundation Project Support Award,
  2.  1st Poster Award in Biomedical Trials, 5th International Bioengineering Congress, 2010
  3. Encouragement Award, 2nd Laboratory Animals Science Symposium, 2010.
  4. 1st Poster Award, 5th Ege University Faculty of Dentistry & 14th EBDO International Congress and Scientific Exposition, 2010.
  5. 2nd Poster Award in Biomedical Trials, 5th International Bioengineering Congress, 2010
  6. Poster Award, IVth National Congress Bioengineering with International Participation, 2008
  7. Honour Award, Veterinary Medicines Society, 2005.
  8. 4th Poster Award in Project Competition, EBILTEM 2004
  9. 2nd Poster Award in Project Competition, EBILTEM 2004
  10. Veterinary Microbiology Society, Ankara. 20 years’ service in Veterinary Microbiology Society
  11. BANAT Scientific Research Award on Periodontology, Ankara, Turkey, 1998. “In vitro evaluation of the effect of serum proteins on periodontal regeneration”, G. Tuter, M. Yalim, SI. Gürhan, K. Balos.
  12. 18th National & Reconstructive Surgery Congress, Bursa, Turkey, 1996, Second Award in Clinical Trials, “Preparation of graftable epithelium with human keratinocyte cell culture”, C. Acıkel, I. Gürhan, N. Selmanpakoglu.
  13. Eczacıbasi–Procter & Gamble Oral & Dental Health Scientific Research & Encouragement Award, 1996. “Evaluation of effect of cyclosporine A on the intracellular Ca quantity of gingival fibroblasts” , M. Yale, G. Tuter, I. Gürhan, A. Bodur, E. Copur, I. Kurt, M. Serdar.
  14. Vasif Anil Award, Biomedical Technology Congress (BIOMED-3), Bursa, Turkey, 1996. “Cultivation of human trophoblasts on fibroblast feeder-layer”. A. Gurpinar, Gürhan, I., A. Denizli, M.A. Onur, A. Tumer, E. Piskin.
  15. 4th Best Poster Award of Biomedical Technology Congress (BIOMED-4), Istanbul, Turkey, 1997. “Initial attachment of human gingival fibroblast cells onto biodegradable membranes in vitro: Light and electron microscopic evaluation”. B. Unsal, G. Ozcan, M. Yalim, G. Tuter, B. Kurtis, I. Gürhan.
  16. British Council Scholar, invited investigator, 1995(Jan.-March) CAMR, European Collection of Animal Cell Cultures (ECACC), CAMR, Wiltshire, United Kingdom.
  17. TUBITAK (Turkish Scientific & Technical Research Council) Scholar: "New Generation Vaccines: The Role of Immunology “, NATO ASI, Summer School, 1992(July), Cape Sounion, Greece.
  18. Veterinary Microbiology Society, Ankara. 20 years’ service in Veterinary Microbiology Society
  19. FAO scholar: "Advanced Techniques in Animal Cell Culture”, Surrey University., Microbiology Dep. 1988(Sep.). Guildford, UK.
  20. EEC scholar: Training on the hybridoma technology. Pasteur Inst., Medical Virology Dep., Paris, 1986(March) France.
  21. EEC scholar: Training on the monoclonal antibody production technology, Inst. Zooprofilattico Sperimentale., 1986(April) Brescia, Italy.
  22. EEC scholar: Training on the subject of animal cell bank organization, Pasteur Inst., Medical Virology Dep., Paris, 1979 (Sep._Nov.), France.
  23. FAO scholar: Invited Investigator, Istituto Zooprofilattico Sperimentale, Padua, 1978(Sep. - Oct.) Italy